Hi
there seem to be enough evidence about the lack of beneficial effect of treatment of the PDA!
The approach to a hemodinámica significant ductus has changed significantly in the last 10 years. 
Years ago we weee so obsessed that indocin prophylaxis was standard in many NICUs and early treatment became standard across the board. 
I remember going to Dr Clayman  PDA lecture at PAS where the PDA was seen as a demon
many babies had  been exposed to surgical ligation with a known consecuentes of a surgery on a small premie baby 
since William Benitez published his meta analysis about PDA there has been a definitive change in some centers on how to approach it and some has gone away from early treatment and surgery 
there are other centers that continue to ignore the Trent and treat the PDA like we used to 10 years ago.
we I have noted in my practice is that regardless of the PDA size; baby that are on Mechanical ventilation after 7-10 days we give a course of tapering Decadeon (DATRT) and they get extubated
i Belice fluid/sedation/lung protective strategy and steroids when use appropriately will result in better outcomes for our micro premie of 22-26 weeks
whats are you doing in your practice?
thanks
 
 

Had a chance to attend #TEIBIO - 
Transference (of knowledge Entrepreneurship ) & Innovation in Biotech .
inspirational talk on rare diseases awareness day and topics were bringing hope to paediatrics #nicu: by address solutions to Neonatal Congenital Heart #CHD ❤️and better tolerance heart transplant.
- 💡Crazy scienceco-founder Dr. Beatriz Salvador shows us how her team have found a non-invasive treatment for Congenital Diaphragmatic Hernia. 
They were able the hole in CDH by regulating the immune system. 
Have had 75%success rate and animal models have shown low toxicity.
Currently recognized as an orphan drug EU - finalize animal model trial in a non-rodent model. 
Hopes to begin clinical trials in 2025 with the esteem collaboration of Dra. Mayte Vallejo, del Instituto para la Investigación Biomédica del Hospital Universitario La Paz de Madrid (IDIPAZ) y paciente advocacy association «La vida con Hernia Diafragmática Congénita» located in Mérida, Spain.
Crazy Science & Business S.L.   
https://crazyscience.es

 
 
Rafael C. Rocha   THYTECH founded a start-up to find a solution to avoid rejection in❤️ transplant in babies. Here the team are using an infant's timus cell to avoid rejection.
https://es.linkedin.com/company/thytech
 
Thanks to Carlos Cosculluela Chocarro for the shout-out. @FundacionDRO AsBioMad 
 

The 99nicu.org web site is built on the Invision Power Board software. 
In the next version (v5) there will be a major overhaul of the user interface, allowing for an even better way of presenting and browsing content here.
You can get a sneak preview in the video below (a bit techy, but still )
 

I don’t need to expand on how Internet and social media have shifted the paradigm for professional discussion. You know this!
Painful it is, but I wanted to share that I have decided to close my Twitter/X account. I will miss you tweeps. But... see you soon elsewhere!
I started to build a network on Twitter in 2009, exploring this new channel for communication about research and medicine. Twitter was different then, compared to what X has become. In the earlier years, Twitter impersonated open, high-level and cross-professional discussions. Despite different opinions shared, the feed was a friendly gathering. If you posted something seemingly controversial (or something not at all controversial about Covid-19, liberal democracy values, suffering among immigrants, or aggressive warfare), people commented in a respectful manner. You did not get a load of automated bot replies (from "verified accounts" with like ~10 followers) telling you were a moron and should XYZ!
Importantly, #NeoTwitter, #NeoEBM and #foamneo all grew into valuable resources. I am so grateful for connecting with you and other wonderful people there. It has indeed enriched my professional life, and often made me think twice.
With X and the new leadership by Musk et al (btw, is there even an “al”?), I have simply taken the consequence of not compromising with my values. That’s why I will delete my X account soon, after saying good bye to comrades there. The principal reason is that I don’t want to contribute to a communication platform where hate speech, conspiracy theories, and fake news is given this much space. The world of today is complicated enough as it is.
Although my own feed is still pretty OK, I feel that sharing a communication platform with the “dark side” (and don’t underestimate the force of it), implies that my presence there, as a person and as a professional, legitimate the bad stuff. In fact, this might even be an intentional business strategy of the X management team.
There is certainly some “alternative cost” to rebuild a neonatal network on a new platform. But I am fine with that. For myself, this is a step worth taking to get rid off the feeling that I am also, to some symbolic extent, feeding the trolls on X.
For the time being, I will stick to LinkedIn, while hoping to rebuild a network feed on our NICUVERSE Mastodon-server and/or on Bluesky. So, might see you there
And of course, maybe the future holds a renaissance for 99nicu.org with its older-school web site-based discussions.
Please note that this is a personal decision and about my own Tw/X account. However, within the 99nicu Team, we are also discussing an X-it strategy, but we need to make sure we have the organization's best interest in mind. And, with our upcoming conference, we may choose to keep the 99nicu account up and running to for sharing the word about our conference plans. After all, #NeoTwitter is still a great place for reaching out.
Thanks to the Verge for making the graphics illustrating this post