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  • New 99nicu Poll: probiotic use in the NICU


    The awaited probiotics UK-trial is now published, and the results are showing that a single bacteria (Bifidobacterium breve BBG-001 in very preterm infants) does not reduce the risk of NEC, late-onset sepsis, or mortality. In short, a negative trial of good quality methodologically.

    However, the results contrasts against the ProPrems trial, similarly powered and well-designed, but the probiotics in that trial included a 3-strain preparation. Also, the Cochrane review from last year expressed strong recommendations that probiotics should be offered to preterm infants.

    We have started a new 99nicu Poll about probiotic use in the NICU.

    Please go there, vote, and share your experience and expertise.

    Here's the URL: http://99nicu.org/forums/topic/1901-probiotics-in-very-preterm-infants-how-do-you-do-now/

    Edited by 99nicu.org

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    I think what this shows is that this particular strain of probiotics is ineffective.  Herein lies the problem with the huge glut of info on probiotics and that is the wide variation in products that have used.  I suspect probiotics will not help all premature infants but rather a subset which we have yet to identify.  Add to this that so few centres are comparing the same bacteria and it is no wonder the results are inconsistent.


    Based on the work being done here in Manitoba on the infant microbiome (see work by Meghan Azad) it is clear that not only do the bacterial genus and species matter but whether they are active and to what extent that influences health.  I am not sure how we will ever settle the probiotic discussion but it may become entirely moot as we expand donor breast milk programs which I think is the better way to go.


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