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Alex

surfactant treatment in pneumonia?

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Dear colleagues, do you have experience with surfactant treatment in innate and nosocomial pneumonia? Many thanks for attention.

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Interesting idea. We have on individual occasions given surfactant to our patients, mostly without any significant respiratory improvement.

Surfactant levels seem to be reduced in pneumonia http://www.atsjournals.org/doi/abs/10.1164/ajrccm.153.1.8542113#.U-I7bGNBl14

There seems to be some recent research on this issue though:

in mice: http://onlinelibrary.wiley.com/doi/10.1111/j.1399-6576.1996.tb05580.x/abstract

possibly it is another phospholipid that is disrupting the function of surfactant during pneumonia: http://www.ncbi.nlm.nih.gov/pubmed/?term=20852622

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