JACK Posted August 23, 2007 Share Posted August 23, 2007 We have started using Sodium acetate as an additive in our TPN. It has shown to be very beneficial in neonates. A nice abstract link is as follows (http://pt.wkhealth.com/pt/re/adcn/abstract.00042223-199707000-00003.htm;jsessionid=GNySJG81pcQhGQHwc2GLMGJSnDFxkyGgbZnDvfTHGPtgtDTX9MpJ!-362743511!181195628!8091!-1) I just wanted to ask the community out there how is their experience with this additive? Any complications? What about use in nenonates with cholestasis? Does acetate conversion to bicarbonate work in presence of severe liver disease? How does the increased pH affect the ultimate Ca and PO4 stability? Link to comment Share on other sites More sharing options...
Guest charris Posted September 14, 2007 Share Posted September 14, 2007 Thanks for the abstract. We've been using Na acetate in our TPN for a number of years and have the same good results as the study. Just to clarify, the increased pH that they report would be in the baby not in the TPN bag. The TPN bag would likely be a little acidic from ingredients like cysteine HCl, which then would increase calcium & Po4 stability, however when the baby metabolizes the acetate to bicarb the blood pH rises a little. We haven't noticed a difference with acetate conversion to bicarb in liver disease- haven't studied it though. Link to comment Share on other sites More sharing options...
ammar Posted September 18, 2008 Share Posted September 18, 2008 Hi JACK we never used sodium acetate in our practice of TPN because it is not diponible at our hospitals. I would like to know is that absolutely necssary and what harm we made to our premies. Link to comment Share on other sites More sharing options...
doctorf Posted December 15, 2008 Share Posted December 15, 2008 HI i would like to know the dose of sodium acetat to be added in TPN thank you Link to comment Share on other sites More sharing options...
Guest charris Posted December 30, 2008 Share Posted December 30, 2008 This is our standard formula which can be modified as needed: amino acid 3% (Trophamine), dextrose 10%, NaCl 5 mmol/L, Na Acetate 30 mmol/L, K Phosphate 17 mmol/L (= K 25 mmol/L), Ca Gluconate 23 mmol/L, Mg sulph.1.8 mmol/L, cysteine HCl 1200 mg/L, vitamins & trace elements. You can see that most of the sodium is in the form of acetate. Link to comment Share on other sites More sharing options...
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