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mmerocru

Procalcitonin (PCT)

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Hi. 

Somebody use PCT before PCR in neonatal screening of infection in neonates with prenatal  risk  factors?

Actually we use first PCR, and I think it is OK. Some young collegues are very entusiastic with PCT, but I¨m not so sure. 

Thank you

 

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We have tried to use it but have not felt comfortable with the interpretation.

I browsed Pubmed and I could not find any large diagnostic studies (estimating sens/spec, predictive values etc).

Here was one better article: http://www.ncbi.nlm.nih.gov/pubmed/22019570 

Would be great to hear more input from others who may use it!

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8 hours ago, M C Fadous Khalife said:

We use both CRP and PCT and correlating both helps us a lot 

It is very useful when we decide to stop antibiotics 

CPT is more sensitive and specific for infection screening than CRP

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We rely on acute phase reactant if we want to rule out sepsis, as their NPV is higher when you use a bundle of tests, therefore we will use them for not starting antibiotics and length of antibiotic treatment but not for starting antibiotics when symptoms are not specific and no risk factors for LOS.

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