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I have seen 2 newborns recently with hyperinsulinemic hypoglycemia. Both of them settled down with diazoxide.How common is the transient form?

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We also come across infants that clearly have slightly elevated s-insulin (with low blood sugars) despite hypoglycemia.

My limited experience is - diazoxide has worked very well and we have been succesfully withdrawing diazoxide before discharge (like after a week or so).

 

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We come across infants that have e hyperinsulinemic hypoglycemia, few are transit responded to diazoxide the rest turn to be Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) they have Mutations of SUR1. and 2 cases with Donohue syndrome (severe insulin resistance, hyperinsulinemia postprandial hyperglycemia, preprandial-hypoglycemia. 

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