Posted April 2, 20205 yr can procalcitonin be used in neonates ? is it superior then crp ? what is sepis value ? when it is positive (for example premature ruptur of membranes 6 hour after birth or earlier) ?
April 2, 20205 yr The PCT as an Acute phase reactant raises far early than CRP ( within 24 hrs) , but may be after 6-8 hrs . Moreover, the levels have less variability with the regard to the birth weight and gestation , with some studies also confirming its role in prognosis when done serially ( See Neopins) . Hence , this may be better than CRP for the EOS obviously. For now , a negative PCT that persists has a strong NPV and the antibiotics may be stopped /May see the Neopin trial and the Commentary. But remember to look at the nomograms at different age / rather than use only one value
April 2, 20205 yr Author 1 hour ago, Dr Ashish Jain said: The PCT as an Acute phase reactant raises far early than CRP ( within 24 hrs) , but may be after 6-8 hrs . Moreover, the levels have less variability with the regard to the birth weight and gestation , with some studies also confirming its role in prognosis when done serially ( See Neopins) . Hence , this may be better than CRP for the EOS obviously. For now , a negative PCT that persists has a strong NPV and the antibiotics may be stopped /May see the Neopin trial and the Commentary. But remember to look at the nomograms at different age / rather than use only one value Thanks I haven't understood abbrevation "EOS". NPV: negative predictive value?
April 10, 20205 yr We are moving away from obtaining CRPs, CBCs, and/or procalcitonin levels in our NICU and nursery. The EOS calculator is far better as a predictor of early onset sepsis in infants >34 weeks. It is free on line, and there is a free app for iOS software. In babies <34 weeks, we still obtain CRPs and CBCs, but we weigh maternal factors more than lab values.
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