agoz Posted April 2, 2020 Share Posted April 2, 2020 can procalcitonin be used in neonates ? is it superior then crp ? what is sepis value ? when it is positive (for example premature ruptur of membranes 6 hour after birth or earlier) ? 1 Link to comment Share on other sites More sharing options...
Dr Ashish Jain Posted April 2, 2020 Share Posted April 2, 2020 The PCT as an Acute phase reactant raises far early than CRP ( within 24 hrs) , but may be after 6-8 hrs . Moreover, the levels have less variability with the regard to the birth weight and gestation , with some studies also confirming its role in prognosis when done serially ( See Neopins) . Hence , this may be better than CRP for the EOS obviously. For now , a negative PCT that persists has a strong NPV and the antibiotics may be stopped /May see the Neopin trial and the Commentary. But remember to look at the nomograms at different age / rather than use only one value 1 Link to comment Share on other sites More sharing options...
agoz Posted April 2, 2020 Author Share Posted April 2, 2020 1 hour ago, Dr Ashish Jain said: The PCT as an Acute phase reactant raises far early than CRP ( within 24 hrs) , but may be after 6-8 hrs . Moreover, the levels have less variability with the regard to the birth weight and gestation , with some studies also confirming its role in prognosis when done serially ( See Neopins) . Hence , this may be better than CRP for the EOS obviously. For now , a negative PCT that persists has a strong NPV and the antibiotics may be stopped /May see the Neopin trial and the Commentary. But remember to look at the nomograms at different age / rather than use only one value Thanks I haven't understood abbrevation "EOS". NPV: negative predictive value? Link to comment Share on other sites More sharing options...
Dr Ashish Jain Posted April 2, 2020 Share Posted April 2, 2020 EOS : Early onset Sepsis Link to comment Share on other sites More sharing options...
agoz Posted April 2, 2020 Author Share Posted April 2, 2020 eos: early onset sepsis as I found. Link to comment Share on other sites More sharing options...
HickOnACrick Posted April 10, 2020 Share Posted April 10, 2020 We are moving away from obtaining CRPs, CBCs, and/or procalcitonin levels in our NICU and nursery. The EOS calculator is far better as a predictor of early onset sepsis in infants >34 weeks. It is free on line, and there is a free app for iOS software. In babies <34 weeks, we still obtain CRPs and CBCs, but we weigh maternal factors more than lab values. Link to comment Share on other sites More sharing options...
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