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procalcitonin,crp in neonate


agoz

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The PCT as an Acute phase reactant raises far early than CRP ( within 24 hrs) , but may be after 6-8 hrs . Moreover, the levels have less variability with the regard to the birth weight and gestation , with some studies also confirming its role in prognosis when done serially ( See Neopins) . Hence , this may be better than CRP for the EOS obviously.

For now , a negative PCT that persists has a strong NPV and the antibiotics may be stopped /May see the Neopin trial and the Commentary.

But remember  to look at the nomograms at different age / rather than use only one value 

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1 hour ago, Dr Ashish Jain said:

The PCT as an Acute phase reactant raises far early than CRP ( within 24 hrs) , but may be after 6-8 hrs . Moreover, the levels have less variability with the regard to the birth weight and gestation , with some studies also confirming its role in prognosis when done serially ( See Neopins) . Hence , this may be better than CRP for the EOS obviously.

For now , a negative PCT that persists has a strong NPV and the antibiotics may be stopped /May see the Neopin trial and the Commentary.

But remember  to look at the nomograms at different age / rather than use only one value 

Thanks 

I haven't understood abbrevation "EOS".

NPV: negative predictive value?

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  • 2 weeks later...

We are moving away from obtaining CRPs, CBCs, and/or procalcitonin levels in our NICU and nursery. The EOS calculator is far better as a predictor of early onset sepsis in infants >34 weeks. It is free on line, and there is a free app for iOS software. 

In babies <34 weeks, we still obtain CRPs and CBCs, but we weigh maternal factors more than lab values. 

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