Hi, I would like to learn more about hypoxic-ischemic encephalopathy (HIE), can you recommend your favorite articles in the topic?

I can totally read some reviews, or also original research papers if you think they are well written and relevant   animal studies can also be interesting!

Thanks!

 

 

Big topic, and lots of available reads! I would suggest to start off with two review papers, the first one describing long-term outcomes from the key RCTs (like the NICHD and TOBY trials, and the other one about neuroimaging (like a historical overview).

https://pubmed.ncbi.nlm.nih.gov/27863707/
https://pubmed.ncbi.nlm.nih.gov/27673422/

So many to recommend , vital topics . Agree it a good idea to start with RCT TOBY trial/ Cool Cap Here the latest I viewed. 

Human umbilical cord mesenchymal stromal cells as an adjunct therapy with therapeutic hypothermia in a piglet model of perinatal asphyxia - ScienceDirect https://www.sciencedirect.com/science/article/pii/S1465324920309300  by one Dr.Nicola Robertson et al who working on this field + 10 yrs.

3 minutes ago, Jelli KA said:

So many to recommend , vital topics . Agree it a good idea to start with RCT TOBY trial/ Cool Cap Here the latest I viewed. 

Human umbilical cord mesenchymal stromal cells as an adjunct therapy with therapeutic hypothermia in a piglet model of perinatal asphyxia - ScienceDirect https://www.sciencedirect.com/science/article/pii/S1465324920309300  by one Dr.Nicola Robertson et al who working on this field + 10 yrs.

Ooooh! Cool, thanks!!!

 I think I found an interesting study about antepartum and intrapartum risk factors of neonatal encephalopathy. A bit old, but I think still very relevant when discussing the causes of hypoxic ischemic injury with parents!

https://www.bmj.com/content/317/7172/1554.long

https://www.bmj.com/content/317/7172/1549.long

Also there are papers now looking at "cooling outside criteria" which are interesting too e.g. late preterms, stroke.....

This RCT was in adults but suggests worse outcomes in adults undergoing therapeutic hypothermia who have bacterial meningitis.....https://pubmed.ncbi.nlm.nih.gov/24105303/ A neonatal study (Jenkins et al 2013) has looked at immunosuppressive impact of cooling.

Newer possibilities: cooling in NEC?!? https://pediatrics.aappublications.org/content/125/2/e300.short and lots of work now looking at adjunctive therapies like xenon and erythropoetin.....

And perhaps a topic for a separate discussion thread....and I think topical to practice (in UK) cooling in mild HIE?!?

 https://fn.bmj.com/content/105/2/225.abstract?casa_token=urlRBLGeNVgAAAAA:mpPfBX_gPwzVlNLIpUYO9ETpCgdI20zJNzxhuJ2EoqU-hcqW3NGeoqpYXAH9GN-6fZrhsSx-mRk

Great resources, thanks Vicky!!!