Pontus Johansson Posted April 20 Share Posted April 20 Hello all! Just briefly wanted to pop the question if anyone out there have experience in using LDH as a marker for tissue hypoxia and assessment of for instance birth asphyxia, TTN, other? Have seen plenty of studies and some development of different tests, point of care use and would be very grateful to your opinion on if this is something we ought to use? All the best! //Pontus 1 Link to comment Share on other sites More sharing options...
Gustaf Lernfelt Posted April 21 Share Posted April 21 Wouldn’t the use be limited due to too many sources of error? You wouldn’t know if it was the liver or the kidney that took the hit. Link to comment Share on other sites More sharing options...
M C Fadous Khalife Posted April 21 Share Posted April 21 We don't use, not reliable concerning hypoxia Link to comment Share on other sites More sharing options...
CHAKRADHAR MEDDELA Posted April 22 Share Posted April 22 Hi. We routinely do LDH levels in Post-Resuscitation term babies. It is marker of multi organ injury. Increased LDH levels >1050 IU/L in less than 12hrs predicts NE, neonatal encephalopathy. Less than 2085 IU/L carry good prognosis & if more, predicts 55% poor outcome. LDH levels > 3555 & 5090 IU / L were associated with disability and death in cooled babies Ref 1.(Sabir H et al Prediction of outcome methods assessing short-and long-term outcome after therapeutic hypothermia. SFANM 20(2015):115-121) Ref 2. Chakradhar Maddela. A Comprehensive Clinical Approach to Hypoxic Ischemic Encephalopathy in Term Infants: A Review Acta Scientific Paediatrics 5.2(2022):37-44. Thanks. 3 Link to comment Share on other sites More sharing options...
manuel perez valdez Posted May 1 Share Posted May 1 More than a marker of hypoxia in perinatal asphyxia, which has great diagnostic relevance, it is an important indicator of the result of the adaptive metabolic changes from aerobic anabolism to anaerobic catabolism that the fetus has had to operate by redistributing the oxygenated blood flow to noble organs. such as the brain, heart and adrenal glands, sacrificing very large organs such as skin and muscle due to decreased transplacental oxygenation in those cases with intrauterine growth restriction. Together with the concomitant alterations of creatine phosphokinase and the elevation of uric acid measured at the time of birth, hand in hand with the presence of hyperlactatemic acidosis. 1 Link to comment Share on other sites More sharing options...
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