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Does anyone have any experience in using Factor VIIa in controlling hemorrhage in neonates?

Let me include some relevant links here

Strauss T, Kenet G, Schushan-Eisen I, Mazkereth R, Kuint J. Rescue recombinant activated factor VII for neonatal subgaleal hemorrhage. Isr Med Assoc J. 2009 Oct;11(10):639-40. LINK TO DOWNLOAD

Puetz J, Darling G, Brabec P, Blatny J, Mathew P. Thrombotic events in neonates receiving recombinant factor VIIa or fresh frozen plasma. Pediatr Blood Cancer. 2009 Dec;53(6):1074-8. Review. PubMed PMID: 19621430. LINK TO ABSTRACT

Guzzetta NA, Huch S, Fernandez JD, Tosone SR, Miller BE. Use of recombinant factor VIIa for uncontrolled bleeding in neonates after cardiopulmonary bypass. Paediatr Anaesth. 2009 Apr;19(4):364-70. Epub 2008 Dec 30. PubMed PMID: 19143947. LINK TO ABSTRACT

Puetz J, Darling G, McCormick KA, Wofford JD. Fresh frozen plasma and recombinant factor VIIa use in neonates. J Pediatr Hematol Oncol. 2009 Dec;31(12):901-6. PubMed PMID: 19956022. LINK TO ABSTRACT

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If you have used FVIIa in non-hemophilic patients, you can submit your data in this registry

https://trials.cba.muni.cz/sevenbleep/interface_forms/Trialdb.Asp

Factor VIIa (Novoseven) was a drug I used the last week before moving to my editorship at Swedish Medical Journal.

Actually, we used it in this case discussed here: http://www.99nicu.org/forum/showthread.php?15779

We were desperate with uncontrolled subgaleal bleeding, the coagulation specialist adviced us to try this (based on the coag parameters we had). If I recall this correctly, we gave two doses. I do not remember the dose/kg.

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