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Midazolam and the growing brain


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Here are some articles on the topic (I hope this would help you):

Cochrane Review on Midazolam (free article):

Cochrane Database Syst Rev. 2003;(1):CD002052.

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit.

Ng E, Taddio A, Ohlsson A.

Quite a good overview on the topic (mostly animal studies) (free article):

Anesth Analg. 2007 Mar;104(3):509-20.

Use of anesthetic agents in neonates and young children.

Mellon RD, Simone AF, Rappaport BA.

Intresting article about molecular mechanism of several drugs (free article):

Anesthesiology. 2009 Apr;110(4):703-8.

Update on neonatal anesthetic neurotoxicity: insight into molecular mechanisms and relevance to humans.

Patel P, Sun L.

A bit off topic but discusses midazolam in the field of intubation/sedation:

Pediatrics. 2010 Mar;125(3):608-15. Epub 2010 Feb 22.

Premedication for nonemergency endotracheal intubation in the neonate.

Kumar P, Denson SE, Mancuso TJ; Committee on Fetus and Newborn, Section on Anesthesiology and Pain Medicine.

Many greetings from Sweden


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My question arouse from a legal pitfall we´ve had in our country regarding the prohibition of midazolam in the NICU, related to the fact that the preservants (ethyl alcohol I believe) was causing developmental delays in prematures upon follow up. Other colleagues from South America have refer to midazolam as "poison" for the babies. On that respect, I needed feedback on others experiences regarding its use, pros and cons.

Thanks..........I wuld greatly appreciate articles (evidence based medicine) that approve or disapprove its use.

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