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  1. Stefan Johansson

    Stefan Johansson

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Showing content with the highest reputation since 10/21/2013 in Tutorial Comments

  1. Dear @Dr Khalil Ahmad, we would consider use up to ~14 days of life. I have some personal experiences of using it up to 21 days of life (relapses after early initial closure) but this was some 10+ years back. Nowadays we have a more conservative approach for late relapses.
    3 points
  2. As Stefen Said there is no role of antacid while giving Ibuprofen. For first instance why you want to give antacids for Ibuprofen? if it is to prevent gastric irritation then answer is No. As far as RFT are concerned , all these side effects are transient and will resolve with time. all you need to do is to reduce fluids management and reduce if oliguria during therapy with ibuprofen.
    2 points
  3. Hi Stefan, maybe you would like to add this (excellent) review too: Pacifici GM: Clinical Pharmacology of Furosemide in Neonates: A Review. Pharmaceuticals (Basel) 2013;6:1094–1129. There is some growing evidence of concerns about the furosemid interaction with chondrocytes in the growth plate leading to growth restriction: 1. Bush PG, Pritchard M, Loqman MY, Damron TA, Hall AC: A key role for membrane transporter NKCC1 in mediating chondrocyte volume increase in the mammalian growth plate. J Bone Miner Res 2010 Jul;25:1594–1603.
    2 points
  4. Here a really valuable didactic video on loop diuretics: https://www.medmastery.com/blog/loop-diuretics
    1 point
  5. @Hamed we give mostly therapeutic, but that means that virtually all infants <28 weeks get it, and we are very liberal to start it up till week 32. We tend to continue it until week 35-36 (although my personal take is that we should discont it in very stable and well infants around week 33-34, to avoid any side-effects). We do not measure serum levels, but increase up to 10 mg/kg if apneas persists 5 mg/kg. We usually keep the same dose once an infant is stable and then let infants "grow out of the dose" (which is not 100% rational as the turnover of caffeine increase with postconcepti
    1 point
  6. I wonder if it will be useful to add incompatibility clause: Furosemide has a pH of 8.7-9.3 and therefore should not be mixed with acidic solutions of pH <5.5. This includes glucose 5% and 10%, Ambisome®, caffeine, ciprofloxacin, dobutamine, dopamine, erythromycin, esmolol, fluconazole, gentamicin, midazolam, morphine,
    1 point
  7. looks great! flawless!
    1 point
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