Workshop Evidence-based Medicine

When has enough evidence accumulated to change standard of care? How to interpret noninferiority trials?

Barbara Schmidt and Haresh Kirpalani (US)

This is an interactive session to strengthen your ability to apply evidence from the medical literature to your patients. During the first half, we will discuss strategies to help decide when enough new evidence has accumulated to change the standard of care. The goal is to ensure that we adopt new therapies at the right time – not too early and not too late. During the second half of the session, we will review how to interpret non-inferiority trials. We will focus on potential pitfalls of non-inferiority trials, including inappropriate choices of the active control group and of the minimum clinically important difference between the comparison groups that would result in a rejection of the claim of “non-inferiority”.