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Dear colleagues! Please share your experience regarding 2 issues about infusion in preterm infants. Unfortunately there are no solid guidelines but questions of fluid supplementation and parenteral nutrition are obviously important for premature patients. There are considerable differences in proposed volumes of fluid requirement per day in literature. For example, Avery’s Diseases of the Newborn (10th edition from 2018, freshest one) provides following numbers: From the other hand, European Consensus Guidelines on the Management of Respiratory Distress Syndrome – 2016 Update states that “Typically fluids are initiated at about 70–80 ml/kg/ day and adjustments individualized according to fluid balance, weight change and serum electrolyte levels”. From the third point of view, National Guidelines for Parenteral Nutrition of Neonates in Russian Federation has following recommendation for daily fluid requirements: Bodyweight, grams Daily Fluid Requirements (mL/kg/day) 0-24 hours 24-48 hours 48-72 hours >72 hours <750 90-110 110-150 120-150 140-200 750-999 90-100 110-120 120-140 130-180 1000-1499 80-100 100-120 120-130 120-160 1500-2500 70-80 80-110 100-130 120-160 >2500 60-70 70-80 90-100 110-160 Which numbers are closest to yours? 2. 2. Second question. Clinical case J Premature infant with sepsis on Dopamine with edema because of boluses and severe condition. Now there is a beginning of the 3rd day of life. When calculating infusion for him what bodyweight we consider: 1. actual one (plus 15% of birthweight) 2. minus 3-4,5% from birthweight (ideally we need at least 1,5% of weight loss per day) 3. birthweight 4. something else? Thanks a lot!