many times we met with cases with severe neonatal septicemia, in which we use multiple antibiotics and according to the blood culture,yet we still need use of IVIG a single high dose or 4 days smaller dose as recommended , but still we need to give once more after 1 week or more due to persistence of symptoms .

can you help me

afaf korraa

Suffice to say - i.v. immuneglobuline in neonatal sepsis is not standard treatment Cochrane. unfortunately the INIS Trial has not published its results, but according to data shown at Hot Topics 2010 - there is no indication for iv immuneglobuline in neonatal sepsis. furthermore it seems that there has been publication bias in the trials published on i.v. immuneglobuline so far (that is: only studies that showed an effect were published, and most of them were pretty small)

thank you Francesco