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Neobiomics and the vision and mission of ProPrems®

Neobiomics and the vision and mission of ProPrems®

The Dept of Brilliant Ideas proudly presents this 90 sec video about Neobiomics and the vision and mission of ProPrems®. I am grateful and also proud that what the network of people around Neobiomics has achieved. It has been a journey and now is the time to "arrive" at the point we headed for. If you want more info - send me a DM or email stefan@neobiomics.eu. Please note that we only deliver ProPrems® in Europe.  

Stefan Johansson

Stefan Johansson

Innovation - more than the new buzz word in health care?

Innovation - more than the new buzz word in health care?

The new buzz word in health care is “innovation”. Which is a good thing!  I have been in the ecosystem of innovation since 2016 with the startup company Neobiomics and the ProPrems® product, in the Innovation Incubator at Karolinska Institutet (KI DRIVE). There we meet with other startup companies, and we share several of the challenges of operating in the interface between innovation and “traditional” health care. Here's a few thoughts. Innovation can only benefit patients throug

Stefan Johansson

Stefan Johansson

 

Is the hip exam painful?

The Ortolani and Barlow manouvers are probably the two most requested parts of the physical exam that students ask to be shown. We line up several medical students who take turns applying the steps of abduction and then adduction, testing the stability of the hips. We routinely give oral sucrose, position in kangaroo care or breastfeed while performing other noxious stimuli such as heel lancing but at least in my centre give nothing for manipulating the hips in such a fashion. How can we
 

Antibiotic Resistance in NICU: Are phages the answer in the future

After watching a documentary in ARTE about bacteriophages it made me think about how else is antibiotic resistance in NICU.? It available french / German Here the story phages was told. First discovered use by  Felix Derrel to combat infections in the pre-antibiotics era and was later discredited and forget about in the western world Historically they worked rather well, so there is an attempt to bring them back in the light of increasing antibiotics resistance. This rediscovery s

Jelli KA

Jelli KA

Things I wish somebody had told me before I moved to Finland

Things I wish somebody had told me before I moved to Finland

It’s been some time since I last posted here. Many things have changed in my life since then- the most important transition being my decision to move to Finland to work as a research fellow with the Baby-friendly Ventilation Study Group in Turku. The life of a beginning clinical researcher deserves a separate post here (it may even come at some point). To celebrate my first anniversary in Finland I would like to share 3 things I wish somebody had told me before I moved here. Enjoy! 1.Get ny

cathfriday

cathfriday

 

High TLC, CSF high counts with normal biochemistry

Preterm 32 wks born by NVD. No H/O leaking PV or fever in mother. TLC on day1 was 48000, on day 2 was 62000, on day 5 was 35000. Had about 75% neutrophils, normal platelets, 5% metamyelocytes. Started on Cefotaxime and Amikacin on day 1. LP done on day 4 of life showed cell count of 600, all lymphocytes, protein of 187, sugat of 63mg% ( Pre LP RBS 92 mg%). Would you think of starting Acyclovir or treat as bacterial meningitis. CSF HSV PCR later came out to be negative. LP repeated on day 7 of li

delhinn

delhinn

 

Can provision of colostrum prevent late sepsis in infants <1500g?

Oral immune therapy (OIT) has really taken off at least in our units. The notion here is that provision of small amounts (0.2 mL intrabucally q2or 24 hours) can prime the immune system. Lymphoid tissue present in the oropharynx and intestine exposed to this liquid gold in theory will give the immune system a boost and increase levels of IgA. Such rises in IgA could help improve the mucosal defence barrier and therefore lessen the incidence of late onset sepsis. Rodriguez et al described this in
 

Budding academic> BAPM: UK & Health tech review

This September I had the opportunity to go to BAPM-EBNEO to kept Learning a out Neonatology and hopefully network with the EBNEO, so glad I see lots of you  face to face. This kept motivated to finish my PhD as I re-embark in find a new supervisor _only 1.5 yrs to go. I was real hard to let of the clinician in me as , this is my comfort zone. As a budding academic learn I get explore ideas and ways to implement them as bioethicists , as well finding ways to humanize the NIcU via processes. Last

Jelli KA

Jelli KA

 

How non-invasive NAVA could really reduce neonatal bradycardia

Neurally adjusted ventilatory assistance or NAVA is something that has been around for awhile. Available as a mode on the Maquet ventilator it uses an esophageal probe to sense myoelectrical activity in the diaphragm and provide assistance with postive pressure when detected. This is supposed to be better than the more traditional Graseby capsules or sensing based on airflow. Conceptually then if a preterm infant had a typical mixed apneic event with a component of both central and obstructive a

AllThingsNeonatal

AllThingsNeonatal

 

A new system for managing serum glucose with less pokes. This is a good thing.

Glucose metabolism in the newborn can be a tricky thing to manage. Neonates can have significant fluctuation in their serum glucose in the first few days of life which can lead heels to look like pin cushions. How many times have you been asked as a physician if there is anything we can do to reduce the number of pokes? That something may have arrived at least in a feasibility study that could pave the way for this becoming the standard approach to hypo/hyperglycemia in the newborn. This is an i

AllThingsNeonatal

AllThingsNeonatal

Tipping Point

Tipping Point

Many of you already know about my engagement in Neobiomics, a startup company now launching ProPrems® in Europe. I was asked recently if there was a specific event that made me committed to close the gap between need and availability of a safe way to support the intestinal microbiota. Yes, there was a “Tipping Point” that I can share a few words about, without disclosing patient data. The photo below shows the place in my NICU where a preterm infant stayed some years back, being well o

Stefan Johansson

Stefan Johansson

 

How long should delayed cord clamping really be?

The story around cord management after birth continues to be an evolving one. I have certainly posted my own thoughts on this before with my most recent post being Delayed cord clamping may get replaced. Time for physiological based cord clamping. While this piece demonstrated that there are benefits to longer times till clamping is done, it also showed that if you go too long hypothermia becomes a real risk and with it possible complications. At least in our centre the standard that we have tri
 

Question solved? Why HFNC appears to be inferior to nCPAP for preemies.

To be sure there are fans of both HFNC and CPAP out there. I have often heard from other Neonatologists that they use HFNC and find positive results while other centres refuse to use it in favour of the tried and true CPAP. Turning to the literature you will find some conflicting results with some studies suggesting equity and others more recently favouring CPAP. There has been speculation as to why one would be superior to the other and now we appear to have some answers as to where the differe
 

Aerosolized surfactant. Can we finally do away with intubation?

I have written about non-traditional methods of providing surfactant to newborns previously. The practice of intubating a preterm infant to administer surfactant and leaving the endotracheal tube in with a slow wean of ventilation is mostly a thing of the past (at least in my units). Strategies have evolved and have seen the development of the INSURE technique, LISA methods, use of an LMA to delivery surfactant and even simple deposition into the pharynx all with variable success. The Holy
 

High tidal volume during PPV for infants <29 weeks GA linked to IVH

Just about all of our preterm infants born at <29 weeks start life out the same in terms of neurological injury.  There are of course some infants who may have suffered ischemic injury in utero or an IVH but most are born with their story yet to be told.  I think intuitively we have known for some time that the way we resuscitate matters.  Establishing an FRC by inflating the lungs of these infants after delivery is a must but as the saying goes the devil is in the details. The Edmonton
Review on ethics around decision-making - compulsary reading for all NICU staff

Review on ethics around decision-making - compulsary reading for all NICU staff

If you are to read one paper on neonatal ethics this year, I'd argue that this is the one. Late last year, John Lantos, pediatrician and a leading medical ethicist, published a review in NEJM on the ethics around decision-making in the NICU. The paper is not open-access... but you can surely get it from within your hospital intranet or your university/hospital library. We have a fantastic toolbox in the NICU. We can provide live-saving treatments and support. Most newborns in the NICU
 

Developmental outcomes for extreme preemies after delivery room CPR.

We have all been there.  After an uneventful pregnancy a mother presents to the labour floor in active labour.  The families world is turned upside down and she goes on to deliver an infant at 27 weeks.  If the infant is well and receives minimal resuscitation and is on CPAP we provide reassurance and have an optimistic tone.  If however their infant is born apneic and bradycardic and goes on to receive chest compressions +/- epinephrine what do we tell them?  This infant obviously is much sicke
 

Exclusive human milk diets may overcome programming for the metabolic syndrome

The metabolic syndrome describes the development as an adult of centripetal obesity, high blood pressure, high triglycerides, elevated blood sugar and low HDL cholesterol. These constellation of problems significantly increase the risk of cardiovascular disease, stroke and diabetes. The origins of this syndrome may begin in the newborn period as previous research has noted an association with infants who are born SGA and development of insulin resistance later in life as in the paper Insuli
Sim Devices for teaching NLS & ALS:Day @EMS2019

Sim Devices for teaching NLS & ALS:Day @EMS2019

Last month I got a chance to day pass at ems2019 to get an update on hospital tranfer#picu by la paz and update on  ilcor peadiatric resus by Dr Maconochiel who gave us an insight into how guidelines are elaborated -quite complex.I also the tech lover and intetact  resus decives. The   Mechanical for compression in for fevices look impressive , and fumctional .I was suprised to see many there are available to date x adult use only. My NLS Top medical devices -tried and tested Moniven
 

Can we reduce severe IVH with elevated midline head positioning for ELBWs?

Recently the practice of keeping ELBW infants with a midline head position for the first three days of life has been recommended to reduce IVH as part of a bundle in many units.  The evidence that this helps to reduce IVH has been somewhat circumstantial thus far.  Studies finding that decreased sagittal sinus blood flow, increased cerebral blood volume with increased intracranial pressure all occur after head turns would theoretically increase the risk of IVH.  Raising the head of the bed would
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