Seldenafil in PPHN

[Thabet]

Greetings to all colleagues 

Being an old retired neonatologist  want to know what's  the advances in your work about use of sildenafil in pulmonary hypertension of newborn mainly following  hypoxia at birth?

[Manuel]

Hy Thabet hope you are ok. About your question Im from mexico and unfortunately we dont have nitric oxide on my hospital, so we use Sildenafil in the cases of Pulmonary Hypertension. The reponse in  most cases is adeuately but is not immediately, you have to wait 8 to 12 hours until you really see the therapeutic effect. We make an Echo before and after treatment is installed, and be carefully with hypotension. Pharmakocinetics of oral Sildenafil is acceptable, but is very important to recruit the best you can the lungs, since some times its only this point that is crucial to reverse the increase of pulmonary vascular resistance. Hope this help you

[Thabet]

11 hours ago, Manuel said:

Hy Thabet hope you are ok. About your question Im from mexico and unfortunately we dont have nitric oxide on my hospital, so we use Sildenafil in the cases of Pulmonary Hypertension. The reponse in  most cases is adeuately but is not immediately, you have to wait 8 to 12 hours until you really see the therapeutic effect. We make an Echo before and after treatment is installed, and be carefully with hypotension. Pharmakocinetics of oral Sildenafil is acceptable, but is very important to recruit the best you can the lungs, since some times its only this point that is crucial to reverse the increase of pulmonary vascular resistance. Hope this help you

 

Thanks  the reply is helpful and comprehensive