https://neoreviews.aappublications.org/content/21/3/e165?sso=1&sso_redirect_count=1&no-redirect&nfstatus=200&nftoken=3677b4da-bef4-4313-bdde-60cd616e386e&nfstatusdescription=SUCCESS%3a+Local+token+is+valid      

Hi everyone, I just read this article and wanted to ask about your opinion. Do you have any experience using Milrinone in cases of PPHN In my NICU we don't have nitrous oxide and we recently had a case of PPHN I used Dopamine and Dobutamine but after reading this article I am not sure whether that was the optimal therapy. I highly appreciate your input.

It's a good drug in newborn babies with pphn with RV dysfunction (sy normotension ) Very often I use milrinone. I usually don't give the loading dose. I use milrinone infusion 0.36migr/kg/min in NS. If baby hypotensive, give a bolus of NS before starting milrinone infusion. 

Thank you for your input, that's really helpful!

In our NICU we have been using milrinon for more than 1 year for all admitted newborns diagnosed with pphn,with the help of our pediatric cardiologist.it is very beneficial,

https://mhnpjournal.biomedcentral.com/articles/10.1186/s40748-018-0093-1

This is the protocol of a recently finished trial that has not been published to by knowledge.

We have used IV epoprostenol in some cases with iNO refractory PPHN showing very good response. 

https://www.nature.com/articles/s41372-018-0179-7

 

used it when the response to other drugs is poor. Very useful