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Good time for you, dear colleagues! I wish to ask about your Bevacizumab and Ranibizumab experience in ROP.

Some earlier we star Ranibizumab injections in babies with ROP. We used it with local anesthetic expose in our third case. It was very easy for us and baby, especially for his respiratory statues (severe BPD, with PH in anamnesis). Innovation for us was no general anesthesia for Lucentis injections use.

All our colleagues use fentanyl, ketamin and other intravenous anesthetics in same cases.

If you Avastin or Lucentis use in ROP treatment, what type of anesthesia you prefer?

Many thanks for your attention.

Sorry. With good result for both eyes.

  • 2 weeks later...

We have been using analgosedation for AntiVEGF-Injections for years. We start with 0,1 mg/kg Midazolam (sedation) during preparation time (desinfection, draping inspection), the give Atropine (1:10 0,1 ml/kg, also to avoid oculocardiac reflex-bradycardia), shortly before injection 0,5 mg/kg Ketamine (analgesia) slowly iv (time when ophthalmologist marks injektion site). If the baby is still moving too much add 0,05-0,1 ml/kg Propofol 10%. Respiratory support during procedure ist mononasal CPAP via Perivent T-piece (option to manually ventilate in case of apnea, sometimes as reaction to ketamine, especially if injected to fast). As the usually do both eyes: repeat Midazolam/Ketamine/Propofol as needed.

  • Author

Many thanks, for answer! 5 days ago we repeated out experience with good result, with low flow O2. Only one think disturbed baby. He was hungry.

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