Thrombocytopenia:

Neonatal Alloimmune (Isoimmune)

severe, with platelet counts often ≤10,000/μL in the first day of life.

The maternal platelet count is normal

increase risk for intracranial hemorrhage, both prenatally and postnatally. diagnosis: clinical

The treatment: transfusion of washed irradiated maternal platelets. Irradiated, random-donor platelet if active bleeding & maternal platelets are not immediately available.

Intravenous γ-globulin (1 g/kg daily for 2 days) or corticosteroids ( methylprednisolone 2 mg/kg per day), or both

Elective cesarean section has been advocated for infants at risk

Thrombocytopenia Resulting from Maternal ITP (autoimmune thrombocytopenia)

The mothers with ITP, lupus erythematosus, or other autoimmune disorders.

milder than isoimmune thrombocytopenia≤ 50,000/μL is only about 3%.

bleeding in these patients usually is not severe.

A platelet count ≤40,000 to 50,000/μL a useful indicator for starting therapy.

Intravenous γ-globulin (1 g/kg daily for 2 days) . Corticosteroids (methylprednisolone, 2 mg/kg per day) .

Other condition: blood group O-B incompatibility, Wiskott-Aldrich Syndrome, TAR SX, CMV and rubella, HIV infection. trisomy 13 & 18, Post exchange transfusion

Maternal drug ( tolbutamide , thiazide, quinidine)

Hi!

I'd like to add a great article about neonatal thrombocytopenia that is worth reading:

Blood Rev. 2008 Jul;22(4):173-86. Epub 2008 Apr 22.

Thrombocytopenia in the neonate.

http://www.ncbi.nlm.nih.gov/pubmed/18433954 (sorry not free)

Greetings

Dirk

Hi, thanks, I read its abstract.I could not read full text.

Best wishes