low-molecular- weight heparin in pregnancy use

[Alex]

Dear colleagues!

I meet a cases with different hemorrhage locations (4 intracranial, 1 in adrenal hematomas in both glands). All stories communicated with low-molecular- weight heparin use in pregnancy.

Some later I sow in literature a case about subdural intrauterine hematoma of fetus associated with low-molecular- weight heparin use.

Do you have information about complications in newborns after heparin administration in pregnancy?

Thanks to you. Alex.

[Francesco Cardona]

Interesting case, Alex. Admittingly the literature on fetal complications after LMWH is sparse. I assume you are relating to this case study (Bauder et al.)

Most of our data on LMWH and placental transfer are based on studies in the 80s. It is generally thought there is no placental transfer of LMWH, although the effect of factors like preterm delivery and placental complications are unknown.

So far the recommendations are that LMWH is safe during pregnancy VTE, Thrombophilia in pregnancy - Guidelines 8th ed.