What is the significance of high total leucocyte count as a part of routine and or septic screening?

There is no significance of high WBC count as part of sepsis in Neonate alone, look for others markers like high IT ratio, high CRP etc.Plus clinically. Low WBC count is more significant than isolated Leukemoid reaction

How much high? We have found a congenital myeloid leukemia presented as a fetal hydrops with a WBC count of 250.000 at born