Preterm IUGR/SGA and elevated IRT

Posted July 13, 200717 yr

Good morning eveyone,

I am curious, Is anyone else seeing an increased number of IUGR/SGA premies with and increased IRT on newborn screening? Since starting my fellowship, I've notice that frequently our SGA babies are having abnormally evelated IRTs on newborn screen.

Have a great day

Kelly

July 13, 200717 yr

comment_664

hi , what is IRT?

July 13, 200717 yr

comment_666

I'm sorry about using an abbreviation the might not be universal. IRT is immunoreactive trypsinogen

July 20, 200717 yr

I'm sorry about using an abbreviation the might not be universal. IRT is immunoreactive trypsinogen

Interesting observation!

Do you routinely check IRT in SGA infants?

(We don't)

July 23, 200717 yr

comment_676

Interesting observation!
Do you routinely check IRT in SGA infants?
(We don't)

Immunoreactive trypsinogen (IRT) is assessed on our newborn state screen, to screen for CF.

July 24, 200717 yr

Have you looked for the causes for fault positive causes for the investigation

July 24, 200717 yr

Immunoreactive trypsinogen (IRT) is assessed on our newborn state screen, to screen for CF.

Could this finding be related to the blood flow re-distribution in utero of IUGR infants - that the reduced circulation in the abdominal organs somehow lead to elevated IRT? Have you checked Pubmed, your question may be a nice and well defined research idea?!

4 months later...

December 13, 200717 yr

comment_905

hi all

IRT is a simple tool for population screening that has been used several years ago in France; if it returns positive,it should be confirmed by a sweat chloride testing and eventually by molecular biology. A lot of false positive results have been described but I'm notaware of any relation to IUGR/ SGA. Keep us knowing results of your searches please.