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SafeBoosC-III trial - cerebral oximetry of ELBW did not reduce risk of death or brain injury

Will the SafeBoosC-III impact your clinical practise?  

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The SafeBoosC-III trial is now out in NEJM (https://www.nejm.org/doi/full/10.1056/NEJMoa2207554)

I know lots of effort has been put into this study, 70 NICUs in 17 countries included 1600 extremely preterm infants, randomised to either cerebral oximetry in the first 72 hours or usual care (without such monitoring). Primary endpoint was death or USG-diagnosed severe brain injury at 36 weeks.

No differences found, the primary endpoint occured in 1/3 in both groups.

How will this study impact your care?

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