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Nephrogenic Diabetes Insipidus in neonate

Amirmasoud Borghei
in Fluid & Electrolyte Management

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Dear sir

A 20-day-old term infant presents with lethargy and polyuria. Family history is significant for congenital Nephrogenic Diabetes Insipidus (NDI) in an older sister. Initial laboratory evaluation reveals a serum sodium level of 156 mEq/L. What is the optimal initial management strategy for this neonate, including the target rate of serum sodium correction and appropriate pharmacological intervention?

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