December 10, 200817 yr Dear collegues! Do anyone have an experience of treating nonates with congenital inherited trombophilia, caused by homozigote mutations (PAI-gene-mutation, methylenetetrahydrofolatreductase - gene-mutation). Now we have such a baby with problems, caused by both hyper- and hypocoagulation at the same time (this baby experienced peripheral lower extremity vene trombosis and had a large clinically-silent tromb in left atrium shortly after birth, nearly at the same time - gastric hemorrage). This baby was treated for suspected neonatal infection with one course of antibiotics. We suggest that coagulation problems were provoced by infection. Both parents have verifyed trombophilic mutations. Now (2 weeks later) trombosis resolved, but future management still seems unclear !!?
December 11, 200817 yr Interesting case! I wished I could give you advice, but I have no personal experience in a case like this. No hits in PubMed?
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