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Kacubitt

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    New Zealand
  1. Hi, A case of ex micropremmie with IUGR who has severe PPHN and BPD. Following a severe PPHN crisis experts suggested trial of Bosentan in additional to the sildenafil already started. further course of oral steroids also started. Worked well and weaned ventilation over two weeks. I have minimal experience with Bosentan and wondered how much it is being used as an adjunct? Recognising used as a second line agent when things are in extremis. (no response to iNO). Questions such as typical length of courses being used? Successes? issues? no hepatic impairment at present. Thanks!

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