Hi, A case of ex micropremmie with IUGR who has severe PPHN and BPD. Following a severe PPHN crisis experts suggested trial of Bosentan in additional to the sildenafil already started. further course of oral steroids also started. Worked well and weaned ventilation over two weeks.
I have minimal experience with Bosentan and wondered how much it is being used as an adjunct? Recognising used as a second line agent when things are in extremis. (no response to iNO). Questions such as typical length of courses being used? Successes? issues? no hepatic impairment at present.
Thanks!