Dr.Ram

There are no direct comparative studies between these 2 surfactants. In a retrospective study, better survival and less cost were assciated with Curosurf use than with infasurf. Also, composition of curosurf is different than infasurf. Curosurf contains the highest amount of phospholipids (higher than Infasurf) and highest amout of anti-oxidant phospholipids, plamalogens. Alveofact, which is prepared very simialr to Infasurf contains very little plasmalogens. Furthermore, 4 large randomized controlled trials comparing infasurf with survanta have shown no differences in mortality, BPD, or dosing requirements. However, 4 studies comparing curosurf with survanta has shown better survival, less dosing, faster weaning, and cost effectiveness in favor of curosurf. We have used exosurf, survanat, infasurf and curosurf. Based on the published studies, we switched to curosurf and we have been very pleased with using Curosurf in our NICUs.

We reviewed the published studies. We are not comfortable in using it yet in our prerm infants. We feel, more studies are needed.