Some thoughts from a former pathophysiologist: the aim is to restore skin microcirculation. You surely tried to modify most of the components of edema formation, phlebohypertension (RF? HF?), oncotic/hypoproteinaemia, membranogen (sepsis? etc), but what can we do with the lymphatic component? At first, lymphatic insuff is dynamic, more efflux than the capacity, but beyond a point mechanical component (compression by the edema) becomes also important. Can we help the lymphatic system to bring back the excess fluid, to give space for the microcirculation? Lymphatic massage is well known in adults, but is there anybody practising it in NICUs as a therapeutic tool?