Medication & Pharmacology

Hello again, as you know there are several surfactant brands around. Which surfactant do you use and why?

Hi, While working the past couple of weeks, there has been some discussion on the possible membrane stabilizing effects of hydrocortisone. Is this something you would consider in your practice, in which cases, and what dose would you use? Whats is the evidence and rationale behind it? Best, Gustaf

Hi Everyone! Our Pharmacy told us, that there is an rising shortage of phenobarbital. Being 1st line treatment for neonatal seizures again, this brings some problems with it. What would you prefer as 1st line treatment instead? - Guidelines are kind of favouring Phenytoin as an alternative - but has more significant sideefects. - Levetiracetam? Not that promising, right? Any alternatives? Best wishes, Bernhard

We have come across that medicinal products have become unavailable. Our three latest examples are dextrose gel used for hypoglycemia management (I think this is a food supplement, but still) iron drops for supplementation preterm infants (so, used a lot!) multivitamin drops for preterm infants (finally back on the shelf...) @Bernhard Csillag also posted about phenobarb (see link below) Do you share this experience in your various contexts? I understand that newborns and especially preterm infants are small patient groups for companies to "build business around", and that we have less "power" than say cardiologists working with much la…

I just came across some papers about etomidate for sedation - causing no haemodynamic problems, but I hardly find any paper or recommendation for or against using etomidate in neonates. What I learned so far: - No haemodynamic suppression - Not analgetic - very often onset of myocloni - High tone of pharyngeal muscels - so relaxation needed - Adrenal suppression - in a relevant duration? That one could be a relevant argument against using it in neonates. - 0,3 mg/kg/Dose - Don't know anything about neuroapoptosis. Any experiences? Thank you! best wishes, Bernhard

A cordial greeting from Ecuador. I would like to know if anyone has experience with the simultaneous administration of budesonide and surfactant to decrease the incidence or severity of bronchopulmonary dysplasia. Sincerely, Fernando Agama C. Neonatology Unit Enrique Garces Hospital Quito, Ecuador

Dear All, I wanted to know your unit’s antibiotic choice in 22-23 week babies. We use Benzyl Penicillin and Gentamicin. Dose of Gentamicin is 5 mg/kg/dose @ 36 hourly interval. However we’ve seen actuate kidney injuries with this dosage and we’re wondering whether to change to cefotaxime instead. Would be grateful for your input.

Dear colleague, We are a group of neonatologists interested in neonatal pharmacology. We have launched worldwide this survey to study neonatal analgesia & sedation management. We would really appreciate your expertise and input! We´d suggest you to reflect the current management of analgesia and sedation in your NICU. The name of the Hospital, that we offer to add at the end of the survey, is requested only to avoid duplicated responses and will be deleted before processing the data. No single person or institution will receive information regarding individual answers to the survey. The survey will take 10 minutes or less to complete. In case you have any questi…

Dear 99ers, I would love to hear your different guidelines/approaches/opinions on perioperative antibiotic prophylaxis in preterm and term infants. This is something i would definitely like to improve in our institution. So far, I found no real evidence or guidelines, especially for premature infants. I know various approaches from different departments in Austria, but it would be interesting to have a more international view on this topic. Every comment/reference/expertise on a certain part of this topic (e.g. AB-prophylaxis for cardiac patients, premies, gastroschisis, etc.) is helpful to gather information on this relevant topic. Do you change the regimen al…

Dear Colleagues I am writing to you about your dose range and experiences of using fentanyl infusions for sedation. What is your range and what side effects have you seen. Alok