We did not have good results when we used HFNC as primary therapy.We prefer now Bubble CPAP o NC ventilation and now use HFNC only for weaning from CPAP.
We use Baxter medical water bottles 1 lt capacity and don´t add acetic acid as recommended by some authors.We change the bottles every 24 hours.Dr Antonio Salvadó -Clinica Ciudad del Mar-Viña del Mar-Chile