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Showing results for tags 'kernicterus'.
Just read this editorial in JAMA Peds - about screening/tx against neonatal hyperbili phototherapy and reported long-term risks (excess risk of childhood epilepsy, at least in boys) Although confounding (factor X related to both risk of phototherapy and risk of epilepsy) may well be operating, the First Do No Harm-argument is valid IMHO. Of course, highly elevated s-bili is also something that we fear. Anyone discussing/handling these questions in clinical practise and how to balance? https://jamanetwork.com/journals/jamapediatrics/fullarticle/2733861
As the saying goes "What is old is new again" and that may be applicable here when talking about prevention of kernicterus. In the 1990s there was a great interest in a class of drugs called mesoporphyrins in the management of hyperbilirubinemia. The focus of treatment for many years had been elimination of bilirubin through the use of phototherapy but this shifted with the recognition that one could work on the other side of the equation. That is to prevent the production of bilirubin in the first place. Tin mesoporphyrins (SnMP) have the characteristic of being able to inhibit the en
Presenting the 2nd Presentation of Neonatal CME @ Jamnagar on 25th October. Its : " NEONATAL JAUNDICE- Current Concepts by Dr.Maulik Shah MD. Video link on You Tube: https://www.youtube.com/watch?v=hLMP4FHOdIk. Comments and feedback most welcome.