Does anyone have experience in using Keppra/Levetiracetam in neonatal seizures ?

I have not used Keppra but this article summarizes the experience of 23 cases:

http://jcn.sagepub.com/content/26/4/465.abstract

Thanks for the link.

we have used it as third line after phenobarbitone and phenytoin . And it gives good control

Have you seen any adverse events ?

i have not seen any. It could be due to the fact that we have used them for less than a week and stopped. I remember reading about the RCT being conducted.

We have used levetiracetam in certain cases as well - but not as first line treatment. Our neurologists are very enthousiastic about it. In two cases I remember we did not see any improvement of symptoms though. There are a couple of ongoing trials I believe:

2 are registered on clinicaltrials.org from the US (UCSD and Cincinnati) and I remember that there is also a European multicentre-trial with levetiracetam as first line agent that is ongoing.

So more data is coming.