The AAP committee on fetus and newborn has released its clinical report on PDA in the preterm infant, and it is available on http://pediatrics.aappublications.org/content/early/2015/12/13/peds.2015-3730 

It is a short and well-written report. I especially like the headline "Clinical Trial Opportunities" and the following paragraph stressing that "systematic evaluation in clinical trials...are urgently needed to guide management of these infants". In addition to establishing causal effects of ductal shunting, we need to learn much more about benefits and harms related to our current interventions.

Highly recommended reading!

Interesting read indeed!

I wonder if that means that we will see placebo-controlled trials in PDA studies in the future..

Actually, I think there is a placebo-contr trial in the pipelines within the NICHD network (over there).