Posted May 11, 200816 yr Hello, colleagues! I have a question about therapy of PDA. We are not very experienced in drug therapy for PDA. Sometimes we can use ibu for it. And I wonder: if after the first course the duct remains open, but not significant (for ex. less than 1 mm, no murmur, no clinic), should we continue a therapy (the second course) or not? Thank you
May 12, 200816 yr We would treat conservately if the duct has responded partially and the shunt is definitely non-significant. I would advice that you repeat the echo from after a few days and then as needed, to make sure the duct does not re-open. It is not uncommon that medical treatment result in functional closure but you can still see a small restrictive shunt with colour doppler. Although some factors make such ducts prone to re-open (especially the situation extreme prematurity+septicemia), they commonly close anatomically with time. But it is good to know they do (echo!)
November 3, 200915 yr Hello Stefan, what do you think about the new schedule of ibuprofen (irrespective of gestational age)in PDA proposed by Overmeire? 10-5-5 for newborn younger than 70 h, 14-7-7 for newborn between 70 and 108 h 18-9-9 between 108 and 180 h Have you ever treated your patients with those doses? Maria Antonietta Marcialis MD NICU Cagliari Italy
Create an account or sign in to comment