Posted June 10, 200915 yr Dear Colleagues : Please inform me, If I made a blood culture for a sick neoborn and all antibiotics were not sensitive except Ciproxin antibiotc, Can I give ciproxin? and if it is ok what is the dose? and what are the side effects of this antibiotic
June 12, 200915 yr We use ciprofloxacin in our NICU when we are faced with a similar situation. We use 10mg/kg/dose Q12h
June 18, 200915 yr comment_2086 In our NICU we use fluoroquinolones in gram negative bacillus meningitis (in addition to other antibiotics) due to its better concentration in brain and the fact that it is "vehicled" by neutrophils largely. The anciently "toxicity of ciproxin" can be tempered by some utilization in NICUS for more than 10 years now...
June 18, 200915 yr comment_2089 in our NICU we use ciproflixacin if we have sensitive cultures or when it becomes an antibiotic as empiric but as "vital question". we use 7,5 or 10 mg/kg/dose Q12h
June 28, 200915 yr we have used ciprofloxacin for one patient with pyogenic meningitis(serratia)and it showed marked improvement in CSF examination
June 29, 200915 yr We also use Ciproflox in our unit. Results are promising without any major side effects.
June 29, 200915 yr Hi, I Personally won't advise to use it as a routine as we have lot other antibiotic to use. Although i agree with opinion that chondrotoxicity has never been proven in human neonate but still remains a grey zone. Yes if you have a life and death situation where there is no other alternative definitely one should use it. Reagarding dose in Peds its 10-20mg/kg/24hr divided in two doses (maximum of 800mg in 24 hr). For neonate doses should be determined by sensitivity and severity of sickness. Personally i will go with 10mg/kg/day divided q 12hr. Thanks With regards Kamlesh Kumar Jha MD Neonatology John H Stroger Jr. Hospital Of Cook County Chicago, IL USA
July 20, 200915 yr We have been using Ciprofloxacin judiciously in our NICU's since 9 years and it has been of immense help in Bacterial meningitis, culture sensitive sepsis.Dose 10mg/kg/day bid
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