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Ciproxin in neonates

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Guest Dukstar

In our NICU we use fluoroquinolones in gram negative bacillus meningitis (in addition to other antibiotics) due to its better concentration in brain and the fact that it is "vehicled" by neutrophils largely. The anciently "toxicity of ciproxin" can be tempered by some utilization in NICUS for more than 10 years now...

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Guest olena

in our NICU we use ciproflixacin if we have sensitive cultures or when it becomes an antibiotic as empiric but as "vital question". we use 7,5 or 10 mg/kg/dose Q12h

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  • 2 weeks later...


I Personally won't advise to use it as a routine as we have lot other antibiotic to use.

Although i agree with opinion that chondrotoxicity has never been proven in human neonate but still remains a grey zone.

Yes if you have a life and death situation where there is no other alternative definitely one should use it.

Reagarding dose in Peds its 10-20mg/kg/24hr divided in two doses (maximum of 800mg in 24 hr). For neonate doses should be determined by sensitivity and severity of sickness. Personally i will go with 10mg/kg/day divided q 12hr.


With regards

Kamlesh Kumar Jha MD


John H Stroger Jr. Hospital Of Cook County

Chicago, IL USA

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  • 3 weeks later...

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