Dear Colleagues : Please inform me, If I made a blood culture for a sick neoborn and all antibiotics were not sensitive except Ciproxin antibiotc, Can I give ciproxin? and if it is ok what is the dose? and what are the side effects of this antibiotic

We use ciprofloxacin in our NICU when we are faced with a similar situation.

We use 10mg/kg/dose Q12h

In our NICU we use fluoroquinolones in gram negative bacillus meningitis (in addition to other antibiotics) due to its better concentration in brain and the fact that it is "vehicled" by neutrophils largely. The anciently "toxicity of ciproxin" can be tempered by some utilization in NICUS for more than 10 years now...

in our NICU we use ciproflixacin if we have sensitive cultures or when it becomes an antibiotic as empiric but as "vital question". we use 7,5 or 10 mg/kg/dose Q12h

we have used ciprofloxacin for one patient with pyogenic meningitis(serratia)and it showed marked improvement in CSF examination

We also use Ciproflox in our unit. Results are promising without any major side effects.

Hi,

I Personally won't advise to use it as a routine as we have lot other antibiotic to use.

Although i agree with opinion that chondrotoxicity has never been proven in human neonate but still remains a grey zone.

Yes if you have a life and death situation where there is no other alternative definitely one should use it.

Reagarding dose in Peds its 10-20mg/kg/24hr divided in two doses (maximum of 800mg in 24 hr). For neonate doses should be determined by sensitivity and severity of sickness. Personally i will go with 10mg/kg/day divided q 12hr.

Thanks

With regards

Kamlesh Kumar Jha MD

Neonatology

John H Stroger Jr. Hospital Of Cook County

Chicago, IL USA

We have been using Ciprofloxacin judiciously in our NICU's since 9 years and it has been of immense help in Bacterial meningitis, culture sensitive sepsis.Dose 10mg/kg/day bid