Urban Rosenqvist

Pyridoxin dependent seizures, pyridoxal phosphate dep. seizures and folinic acid responsive seizures are all rare conditions. In our clinic we are now updating our knowledge regarding treatment of these conditions. Do you use Pyridoxin or pyridoxal phosphate in neonatal seizures of unknown cause (no infection, asphyxia etc.)? "... there is no biochemical or chemical reason to believe that pyridoxal phosphate will not be as effective as pyridoxine in the treatment of PDE" and " If pyridoxal phosphate is not easily available, pyridoxine should be given as first line therapy. It must, however, not be forgotten that unsuccessful treatment with pyridoxine does not exclude PNPO deficiency. " taken from Archives of Disease in Childhood 2007;92:659-661, Robert Surtees1, Nicole Wolf2 ...suggests that, if available pyridoxal phosphate is preferred. Is this in line with your practice? Do you have any experience on folinic acid responsive seizures? edit: also, pyridoxal phosphate in infantile spasm - your opinion?