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JPinheiro last won the day on February 26 2019

JPinheiro had the most liked content!

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About JPinheiro

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    Albany Medical Center
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    Albany, NY, USA

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  1. I agree with Stefan. With size 2.5 ETTs, the Neofit plates are difficult to tighten "just right". They are often too loose and let the ETT slide, or, if tightened more, they can crimp the ETT and impede passage of a suction catheter. Otherwise, the device works fairly well. We have also tried Neobar, and used modified cord clamps for years. There is no evidence of a clear advantage of any particular system, and our experience doesn't point to a clearly superior method, either. We think we might have had less unplanned extubations with the locally modified cord clamps, but we didn't rigorously track unplanned extubation rates back then, so we really don't know.
  2. Stefan, this is a difficult problem for 2 reasons: uncertainty with diagnosis of NEC, and limited evidence on what constitutes adequate treatment for NEC of various degrees of severity. The diagnosis of pneumatosis intestinalis versus gas bubbles in stool is difficult; there is commonly lack of agreement on the presence of pneumatosis, and the interpretation is easily biased by other clinical findings. Sometimes, babies with questionable pneumatosis are labeled as having non-specific colitis, or (protein)-allergic colitis, and they may be treated with only bowel rest, or additionally a couple of days of antibiotics, and feedings resumed in 3-5 days if radiological and clinical exams are reassuring. Some neonatologists will have a lower threshold for diagnosing NEC (could be Bell stage 2 in the scenario you gave) and treating for at least 7 days. Even when there is consensus on the presence of pneumatosis, the extent and location of pneumatosis may be important; for example, isolated colonic pneumatosis tends to be seen in older babies and it has a milder clinical presentation. We usually treat for at least 7 days, though some babies' abnormal findings may resolve in 2 or 3 days. I have not seen evidence on gastric decompression. It makes physical sense that intestinal distension and increased intra-abdominal pressure would tend to decrease intestinal blood flow, and they might also cause discomfort to the patient, so we start gastric suction early, until distension and other signs such as bilious aspirates resolve; then, we leave the orogastric tube to gravity drainage. I hope this helps. Joaquim Pinheiro, MD, MPH Professor of Pediatrics Albany, NY, USA
  3. I think that the statement "Roughly 25% of the infants were found to have not received any surfactant,..." is an understandable misinterpretation of a long sentence in the manuscript. The text says that upon gastric aspiration post-treatment, 26% had no surfactant... (... in the stomach), suggesting that those babies actually had the full dose of surfactant delivered to the lungs. It is implausible that surfactant could be delivered via an LMA without any of it being aspirated into the lungs. Both animal and clinical evidence indicate that surfactant delivery via an LMA is quite efficient - though the specific techniques that maximize efficiency still need to be studied.
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