"VOLUME GUARANTEE COMBINED WITH HIGH-FREQUENCY OSCILLATORY
VENTILATION—A NEW ERA
VThf is proportional to the DP generated in each cycle and the length of the inspiratory
time and is inversely proportional to the oscillation frequency; thus, traditionally, an increase in DP or a decrease in frequency to finally increase VThf has been used to
improve CO2 clearance. Also, the frequency has an important role in CO2 removal and has an independent effect on the distribution of the gas within the air-
ways and to changes in the volume when oscillating at or near the resonant frequency of the respiratory system.
Measurement of the VThf gives an important advantage, because there is a close correlation of the VThf and the CO2 washout, described as the diffusion coefficient of CO2 (DCO2) which is related to the VThf2 and the frequency, as follows:
DCO2 =VThf2 x fr
Traditionally, HFOV devices did not measured the VThf, so looking at the transmission of the oscillation to the thorax of the patient has been used to clinically control VThf. Today it is possible not only to measure but also to control and fix the VThf (vol-
ume guarantee [VG]) to maintain it as constant, similar to the VG described for conventional ventilation (Fig. 1), enabling an independent adjustment of the VThf and the frequency. The ventilator, using this new technology, modifies DP to maintain the VThf at the setting value (Fig. 2).
When the VThf is fixed, any change in the frequency does not affect the VThf generated (Fig. 3) but directly modifies DCO2 and CO2 washout in the same direction as in
conventional ventilation.
High-frequency Ventilation
Manuel Sánchez-Luna
Clin Perinatol 48 (2021) 855–868
https://doi.org/10.1016/j.clp.2021.08.003