Neonatal Cyanosis: A Diagnostic Challenge

Welcome to our interactive case-based quiz!

Introduction

A newborn presents with persistent central cyanosis despite good respiratory effort and normal initial evaluations. As your standard interventions fail to improve the infant's condition, you'll navigate through a step-by-step diagnostic journey that challenges conventional thinking. Can you solve the mystery of this persistently blue baby when the usual suspects have been ruled out?

This quiz is based on a case report linked below. Follow along as you work through the diagnostic process of a challenging neonatal presentation.

Important Notes:

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- Each question builds on information from previous questions

DISCLAIMER: We do not guarantee that the "correct answer" in a quiz is 100% correct. Never base your clinical decisions on a quiz!

Quiz Authors: Eliska Mikeskowa @Eli and Katarzyna Piatek @piatkat, with an expert revision by @Mariana Oliveira

Sources:

Carreira R, Palaré MJ, Prior AR, Garcia P, Abrantes M. An unusual cause of neonatal cyanosis…. BMJ Case Rep. 2015 Mar 9;2015:bcr2014208371. doi: 10.1136/bcr-2014-208371. PMID: 25754164; PMCID: PMC4369047. https://pubmed.ncbi.nlm.nih.gov/25754164/

Iolascon A, Bianchi P, Andolfo I, Russo R, Barcellini W, Fermo E, Toldi G, Ghirardello S, Rees D, Van Wijk R, Kattamis A, Gallagher PG, Roy N, Taher A, Mohty R, Kulozik A, De Franceschi L, Gambale A, De Montalembert M, Forni GL, Harteveld CL, Prchal J; SWG of red cell and iron of EHA and EuroBloodNet. Recommendations for diagnosis and treatment of ... . Am J Hematol. 2021 Dec 1;96(12):1666-1678. doi: 10.1002/ajh.26340. Epub 2021 Sep 23. PMID: 34467556; PMCID: PMC9291883. https://pmc.ncbi.nlm.nih.gov/articles/PMC9291883/