Unexpected Complications in a Premature Infant

Introduction

You are called to the NICU to evaluate a premature infant who developed severe jaundice within hours of birth. As critical lab values begin to emerge, you'll need to think quickly and broadly to identify what's truly happening with this patient.

This quiz challenges you to recognize the subtle signs of a rare but potentially fatal complication in neonates. Can you identify the underlying condition and implement life-saving interventions before it's too late?

Important Notes:

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• Each question builds on information from previous questions

• The case follows a realistic clinical progression with laboratory findings and management decisions

DISCLAIMER: We do not guarantee that the "correct answer" in a quiz is 100% correct. Never base your clinical decisions on a quiz!

Quiz Authors: Eliska Mikeskova @Eli and Katarzyna Piatek @piatkat
Expert Revision by: Stefan Johansson @Stefan Johansson and Mariana Oliveira @Mariana Oliveira

This educational quiz is based on and adapted from a case report by Blondel F, et al. published in BMJ Case Rep 2022;15 (doi:10.1136/bcr-2021-246961). The case has been modified for educational purposes, with changes to clinical parameters, timeline, and scope. The complete original case report, which includes additional clinical findings not covered in this quiz, is available at: https://casereports.bmj.com/content/15/4/e246961