March 3, 201511 yr Just learned from the EvidenceUpdates- service that the Cochrane review on Ibuprofen for the treatment of patent ductus arteriosus has been updated. No sensational news really... Ibuprofen is as effective as indomethacin in closing a PDA and currently appears to be the drug of choice. Ibuprofen reduces the risk of NEC and transient renal insufficiency. Oro-gastric administration of ibuprofen appears as effective as iv administration. To make further recommendations, studies are needed to assess the effectiveness of high-dose versus standard-dose ibuprofen, early versus expectant administration of ibuprofen, echocardiographically guided versus standard iv ibuprofen, and continuous infusion versus intermittent boluses of ibuprofen. Studies are lacking evaluating the effect of ibuprofen on longer-term outcomes in infants with PDA. Here the URL to EvidenceUpdates: http://plus.mcmaster.ca/EvidenceUpdates/NewArticles.aspx?Page=1&ArticleID=62564 And here the URL to Cochrane: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003481.pub6/abstract
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