Pyridoxin dependent seizures, pyridoxal phosphate dep. seizures and folinic acid responsive seizures are all rare conditions.

In our clinic we are now updating our knowledge regarding treatment of these conditions.

Do you use Pyridoxin or pyridoxal phosphate in neonatal seizures of unknown cause (no infection, asphyxia etc.)?

"...

there is no biochemical or chemical reason to believe that pyridoxal phosphate will not be as effective as pyridoxine in the treatment of PDE" and

" If pyridoxal phosphate is not easily available, pyridoxine should be given as first line therapy. It must, however, not be forgotten that unsuccessful treatment with pyridoxine does not exclude PNPO deficiency. "

taken from Archives of Disease in Childhood 2007;92:659-661, Robert Surtees1, Nicole Wolf2

...suggests that, if available pyridoxal phosphate is preferred.

Is this in line with your practice?

Do you have any experience on folinic acid responsive seizures?

edit: also, pyridoxal phosphate in infantile spasm - your opinion?

Hej!

We (at the Karolinska univ-hosp) only have specific guidelines about pyridoxin (100mg/kg) in our protocol. If you want a copy (in Swedish), just send me a PM.

Do you know whether pyridoxal phospate is available in Sweden?

Hej!

We (Västerås) also use only pyridoxin but I´ve heard that maybe Akademiska in Uppsala uses pyridoxal phosphate. I´ll call them any day and check - I´ll let you know about it...

In Uppsala they did´nt use pyridoxal phosphate but were very interested in this alternative.

I guess that the hospitals in Stockholm use Pyridoxin and not pyridoxal phospahte?

What about you neonatologists/pediatric neurologists in this forum? Do you have any experience on this subject?