Empiric Antibiotics for NEC

[bimalc]

What are folks using as empiric antibiotics for NEC in your local units?

[Stefan Johansson]

Got this on Twitter

 

 

 

 

 

[Stefan Johansson]

The Stockholm practise is meropenem (as monotherapy)

Prev cefotax and an aminoglyk was first line treatment (+ metronidazol usually...)

[Guest marcydf]

Ampicillin (200 mg/kg), gentamicin and metronidazole even if no perforation.

[egiannon]

We also use ampicillin and gentamicin and add metronidazole  in case of perforation. We very rarely have positive blood cultures at the onset of NEC so we usually stick with this regimen. But it can be difficult to resist the temptation of broadening spectrum in patients that deteriorate.

[Padkaer]

In Aarhus (as tweeted) Ampi/Cefuroxim, gentamycin and metronidazole 😊. We are considering a switch to meropenem though. What are your experience with this Stefan ?

[vidwans]

Ampicillin, Gentamicin. Couple of surgeons also want babies started on Clindamicin in severe NEC.

[gmustafa]

We usually use Ampicillin and Gentamicin. If perforation then add flagyl. If patient detoriates then switch to meropenem.

[M C Fadous Khalife]

Cefotaxime , amikacin and flagyl but in case of deterioration , we broaden spectrum (Lebanon) 

[kishoreyv17]

Ampicillin and Gentamicin in our unit, 2nd line is Cefotaxime and amikacin (level 3 unit in India).