dramitkan Posted April 6, 2022 Share Posted April 6, 2022 Dear All, I wanted to know your unit’s antibiotic choice in 22-23 week babies. We use Benzyl Penicillin and Gentamicin. Dose of Gentamicin is 5 mg/kg/dose @ 36 hourly interval. However we’ve seen actuate kidney injuries with this dosage and we’re wondering whether to change to cefotaxime instead. Would be grateful for your input. 1 1 1 Link to comment Share on other sites More sharing options...
piatkat Posted April 6, 2022 Share Posted April 6, 2022 @RyoItoshima would you like to tell us about your practice from Japan? 1 Link to comment Share on other sites More sharing options...
livia_sibiu@yahoo.com Posted April 7, 2022 Share Posted April 7, 2022 Penicillin and amikacyn Link to comment Share on other sites More sharing options...
Stefan Johansson Posted April 7, 2022 Share Posted April 7, 2022 We would also probably go with bensyl-Pc and Amikacin, the latter dosed every 48 hours (and with checking serum-konc of amikacin before the 2nd dose) 1 Link to comment Share on other sites More sharing options...
varady Posted April 7, 2022 Share Posted April 7, 2022 On 4/6/2022 at 6:56 PM, dramitkan said: Dear All, I wanted to know your unit’s antibiotic choice in 22-23 week babies. We use Benzyl Penicillin and Gentamicin. Dose of Gentamicin is 5 mg/kg/dose @ 36 hourly interval. However we’ve seen actuate kidney injuries with this dosage and we’re wondering whether to change to cefotaxime instead. Would be grateful for your input. Empirical treatment of the first choice is Ampicilin/Gentamcin 1 1 Link to comment Share on other sites More sharing options...
Vicky Payne Posted April 12, 2022 Share Posted April 12, 2022 Cefotaxime first line for EOS in Southampton. 1 1 Link to comment Share on other sites More sharing options...
Francesco Cardona Posted April 12, 2022 Share Posted April 12, 2022 We give Ampicillin / Gentamicin. Dose of Gentamicin is 5mg/kg first dose, then 36h later 3.5mg/kg @24h intervals. Step up from Ampicillin if there is evidence of other bacteria (resistant?) from mother 1 1 Link to comment Share on other sites More sharing options...
NHowold Posted April 21, 2022 Share Posted April 21, 2022 Ampicillin/Gentamicin Gentamicin 5 mg/kg every 48h hours according to the dosage handbook of the American pharmacists association 1 1 Link to comment Share on other sites More sharing options...
Jose Ramon Fernandez Posted April 28, 2022 Share Posted April 28, 2022 Ampicillin plus gentamicin in our NICU, according Neofax dosages. We stop antibiotics if blood culture is negative (48-72 hours) and no clinical or laboratory signs of active infection. 1 2 Link to comment Share on other sites More sharing options...
dramitkan Posted May 3, 2022 Author Share Posted May 3, 2022 On 4/12/2022 at 7:14 PM, Vicky Payne said: Cefotaxime first line for EOS in Southampton. Hi Vicky Do you use Cefotaxime monotherapy? Link to comment Share on other sites More sharing options...
Vicky Payne Posted May 4, 2022 Share Posted May 4, 2022 On 5/3/2022 at 2:56 PM, dramitkan said: Hi Vicky Do you use Cefotaxime monotherapy? Yes- we would add in amoxicillin if concerns re: listeria. No aminoglycoside.... 1 Link to comment Share on other sites More sharing options...
Abdul kasim jaleel ahmed Posted May 5, 2022 Share Posted May 5, 2022 On 4/6/2022 at 8:26 PM, dramitkan said: Dear All, I wanted to know your unit’s antibiotic choice in 22-23 week babies. We use Benzyl Penicillin and Gentamicin. Dose of Gentamicin is 5 mg/kg/dose @ 36 hourly interval. However we’ve seen actuate kidney injuries with this dosage and we’re wondering whether to change to cefotaxime instead. Would be grateful for your input. We use Ampicillin and Amikacin kindly review your Gentamicin dosage in this clinical context can you please high light acute kidney injury is it dose related Acute tubular necrosis? please update thank you Link to comment Share on other sites More sharing options...
Dr Mohamed Ali Posted June 15, 2022 Share Posted June 15, 2022 On 5/4/2022 at 5:49 PM, Vicky Payne said: Yes- we would add in amoxicillin if concerns re: listeria. No aminoglycoside.... Hi Vicky That's interesting as it will save doing drug levels and medications errors as well. My questions - how long since you intoduced this as 1st line for EOS - what's the microbiology advice regarding resisitance as you know most of other units use cefotaxime and vanc as 3rd line Abx. - What's your second and third line Abx policy . Thanks again Link to comment Share on other sites More sharing options...
Bernhard Bungert Posted June 16, 2022 Share Posted June 16, 2022 Gentamycin / Ampicillin. Intervall and Dose acorrding to Neofax. Through Level measuring before second Dose (who determine also peak level?). No 3. Generation Cephalosporines because reported higher appearence of ESBL bacteria. Link to comment Share on other sites More sharing options...
Vicky Payne Posted June 16, 2022 Share Posted June 16, 2022 I can’t tell you how long we’ve used cefotaxime for- but definitely 10 years. You are best speaking to a colleague of mine for more details- if you want to message me your email address I can pass it on? Microbiology data monitored and I assume no concerns with ESBLs! second line fluclox and gent or vanc and gent if a central line present. 1 Link to comment Share on other sites More sharing options...
selja Posted June 29, 2022 Share Posted June 29, 2022 We use amp and gent. With gent doses of 4mg q 48 hours. We haven't experienced any kidney failure. Link to comment Share on other sites More sharing options...
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