Jump to content

JOIN THE DISCUSSION!

Want to join the discussions?

Sign up for a free membership! 

If you are a member already, log in!

(lost your password? reset it here)

99nicu.org 99nicu.org

Antibiotic choice in 22 week babies


Recommended Posts

Dear All, 

I wanted to know your unit’s antibiotic choice in 22-23 week babies. We use Benzyl Penicillin and Gentamicin. Dose of Gentamicin is 5 mg/kg/dose @ 36 hourly interval. However we’ve seen actuate kidney injuries with this dosage and we’re wondering whether to change to cefotaxime instead. Would be grateful for your input.

  • Like 1
  • Thanks 1
  • Upvote 1
Link to comment
Share on other sites

On 4/6/2022 at 6:56 PM, dramitkan said:

Dear All, 

I wanted to know your unit’s antibiotic choice in 22-23 week babies. We use Benzyl Penicillin and Gentamicin. Dose of Gentamicin is 5 mg/kg/dose @ 36 hourly interval. However we’ve seen actuate kidney injuries with this dosage and we’re wondering whether to change to cefotaxime instead. Would be grateful for your input.

Empirical treatment of the first choice is Ampicilin/Gentamcin

  • Like 1
  • Thanks 1
Link to comment
Share on other sites

  • 2 weeks later...
On 4/6/2022 at 8:26 PM, dramitkan said:

Dear All, 

I wanted to know your unit’s antibiotic choice in 22-23 week babies. We use Benzyl Penicillin and Gentamicin. Dose of Gentamicin is 5 mg/kg/dose @ 36 hourly interval. However we’ve seen actuate kidney injuries with this dosage and we’re wondering whether to change to cefotaxime instead. Would be grateful for your input.

We use Ampicillin and Amikacin 

kindly review your Gentamicin dosage in this clinical context can you please high light acute kidney injury is it dose related Acute tubular necrosis? 
please update thank you 

Link to comment
Share on other sites

  • 1 month later...
On 5/4/2022 at 5:49 PM, Vicky Payne said:

Yes- we would add in amoxicillin if concerns re: listeria. 

No aminoglycoside....

Hi Vicky

That's interesting as it will save doing drug levels and medications errors as well.

My questions

- how long since you intoduced this  as 1st line for EOS

- what's the microbiology advice regarding resisitance as you know most of other units use cefotaxime and vanc as 3rd line Abx.

- What's your second and third line Abx policy .

Thanks again

Link to comment
Share on other sites

I can’t tell you how long we’ve used cefotaxime for- but definitely 10 years.
 

You are best speaking to a colleague of mine for more details- if you want to message me your email address I can pass it on?  Microbiology data monitored and I assume no concerns with ESBLs!

second line fluclox and gent or vanc and gent if a central line present. 

  • Like 1
Link to comment
Share on other sites

  • 2 weeks later...

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
×
×
  • Create New...