to be honest, i have no idea if this drugs influence on the long term conditions.. but for the the short term it is proved to be reliable (preventing of ventricular hemmorage for ex)
I think INSURE is probably could be performed without sedation and analgesia in delivery room. But for the late surfactant therapy sedation and analgesia is obligate. We use fentanyl dose: 3-4mikrog/kg, relanium 0.05mg/kg and atropine. have experience of using naloxone after respiratory depression (respiratory recovery in 1 minute) and the following extubation