Medication & Pharmacology

Hello Forum, I would be grateful for your thoughts and experiences on a recent acute episode of hemolysis that was neither incompatibillity nor sepsis, and was eventually attributed to the fact that the infant had been receiving a third generation cephalosporin. Ali

Hello, we used caffeine for treatment of neonatal apneas several years ago but recently caffeine is not available in Lithuania. Using theophylline we see more adverse effects and less effectiveness. Could anybody share information about caffeine preparations(Cafcit etc). What company is a distributor or manufacturer of caffeine in EU - both intravenous and oral forms? I know that in some hospitals caffeine is prepared in hospital pharmacies.Thank you. Rasa

Hello: I have a question for the experts. Recently a pharmacist used ranitidine syrup instead of IV preparation as base for dilution for neonatal po med. The package insert states good for infants up to one month, but we have a practice of not using any med preparations with alcohol in our NICU. what is the standard of care in NICUs?

Does anyone use doxapram for apnea of prematurity in addition to caffeine when the apneas are troublesome? If you do use it have you seen any side effects? Jaideep

We recently had an incident where two of the nurses taking care of a baby on nitric oxide fainted, and one doctor complained of lightheadedness. We had the respiratory therapiest check for any leak but he found the connections are ok and that there is no leak. I wonder if anybody had the same incident and what they did to overcome it. Thanks

Pyridoxin dependent seizures, pyridoxal phosphate dep. seizures and folinic acid responsive seizures are all rare conditions. In our clinic we are now updating our knowledge regarding treatment of these conditions. Do you use Pyridoxin or pyridoxal phosphate in neonatal seizures of unknown cause (no infection, asphyxia etc.)? "... there is no biochemical or chemical reason to believe that pyridoxal phosphate will not be as effective as pyridoxine in the treatment of PDE" and " If pyridoxal phosphate is not easily available, pyridoxine should be given as first line therapy. It must, however, not be forgotten that unsuccessful treatment with pyridoxine does no…

Dear Colleagues, I would like to know your experience about analgesia for laserterapy for retinopathy.He use Paracetamol iv, Midazolam and Fentanyl iv.

Dear Friends: Can anyone could tell me if there really association with Ranitidine and late onset sepsis in neonate. I have only 1 article( Bianconi Simona et al, J Perinat Med 35 (2007) 147-150) but I think there other factors that influencing in the appareance of sepsis. Do we have to stop to use it ( Im agree that dont abuse it, but definitively stopped) Thanks for your opinions. Manuel Bernal Benitez Neonatology Aguascalientes, Mexico Manberbenitez@yahoo.com.mx

Dear Colleagues, I would like to know your experience in such case: We have a baby 30 wk GA with esophageal atresia and tracheoesophageal fistula. he had severe RDS, received 3 doses of surfactant, and large PDA. He developed gastric perforation on day 3 of life. Emergency operation was performed. Postoperatively, he was with chest tube. he was hypotensive, unstable with DIC picture. We could not start fentanyl or morphine infusion at that stage. My question is: what is the best way to mange pain in such cases? Regards

Hi All I have encountered stiff resistance from obstetricians when it comes to using antenatal steroids in mothers who are 1) preeclamptic or uncontrolled hypertensives because it may push up the BP further and 2) Diabetics it may increase the hyperglycemia Would like to know your views