Infectious Diseases

Does anyone have any experience with this drug resistant organism? We recently had 2 babies test positive. Thanks

dear all, I want no know about the best antibiotic to be given to babies as prophylactic when babies are admitted to the nicu

An eye opener !! Antimicrobial policies in the neonatal units of the United Kingdom and Republic of Ireland. Fernando AM, Heath PT, Menson EN. J Antimicrob Chemother. 2008 Mar;61(3):743-5. Epub 2008 Jan 31. http://jac.oxfordjournals.org/cgi/reprint/61/3/743

This is a conceptual - philosophical issue that may also be discussed in the Lounge or in a Blog post. But I decided to post it here! This interesting thread underscored what I have thought about for a pretty long time, that the management of infections has a pretty weak evidence-base. And that we should try do something about it! We do not know terribly much which drug combinations to use and dosing schedules. You may think "so what... are there not a lot of clinical management scenarios that cannot be backed up by the level-A evidence?" I'd say that's a completely valid point, but infections are really an every-day clinical problem. It would not be hard to recrui…

Does anyone use IVIG in the management of neonatal sepsis? If yes what is the indication af starting IVIG in these neonates? What has been your experience with IVIG in sepsis cases?

There has been an increasing incidence of fungal infections in nicu babies . I would like to know from members incidence of fungemia in their units, and whether prophylactic antifungal therapy is stared empirically or they wait for isolation of fungs+ from blood culture or colonisation from surface.

Background In 1988, the World Health Assembly resolved to eradicate poliomyelitis. Although substantial progress toward this goal has been made, eradication remains elusive. In 2004, the World Health Organization called for the development of a potentially more immunogenic monovalent type 1 oral poliovirus vaccine. Methods We conducted a trial in Egypt to compare the immunogenicity of a newly licensed monovalent type 1 oral poliovirus vaccine with that of a trivalent oral poliovirus vaccine. Subjects were randomly assigned to receive one dose of monovalent type 1 oral poliovirus vaccine or trivalent oral poliovirus vaccine at birth. Thirty days after birth, a single…

There is nice review of the efficacy of Prophylactic antibiotics in the prevention of catheter-associated bloodstream bacterial infection in preterm neonates. 1. Lodha A, Furlan AD, Whyte H, Moore AM. Prophylactic antibiotics in the prevention of catheter-associated bloodstream bacterial infection in preterm neonates: a systematic review. J Perinatol. 2008 Apr 10;28(8):526-533. LINK TO THIS FREE ARTICLE Do you use prophylactic antibiotis in your NICU? If yes, then in which patients? What has been your experience? Do share it with us...

I 'm not sure about best practice in congenital CMV infection of preterms. If the baby has thrombocytopenia ( 50.000-60.000 per mm3 peristent, periventricular leucomalasia, but baby looks good, no pneumonia, no septic appearance, normal CSF findings, no chorioretinitis. What is your option about this patient? drug or not? Another patient, baby has cholestasis Direct bil: 7.2 mg/dl ALT:65 U/ml acholic gaita. No thrombocytopenia, no peumonia, no septic appearance. Therapy or not?

Would like to hear how you dose aminoglycosides. The Swedish Neonatal Association has published national guidelines on treatment of bacterial infections. Personally I think the document is well written and up-to-date with current practise internationally. However, Karolinska is always Karolinska , and our clinical practise is characterized by some degree of conservatism (I am a bit diplomatic here). So, we're having an argument regarding dosing of aminoglycosides. For example, if we need to treat a term infant, we discuss whether to administer netilmycin once daily (as the national guidelines suggest) or twice daily (our current practise). What's your practise?